Int J Endocrinol. Alpha lipoic acid is made from mitochondria, which is a cell structure that has powerful functions inside the human body. … DiPardo retired from drug discovery research in 2009 and, since 2010, has covered fitness and well-being for various online publications. There also has been no determination of a clear cut for long-term side effects that can result from taking Alpha Lipoic Acid. As with the previous diabetes studies, oral alpha-lipoic acid supplements were generally less effective or had no effect at all. The term neuropathy refers to a condition characterized by damage to nerves of the peripheral nervous system, the nerves that are not part of the brain and spinal cord. Can CLA Supplements Help With Weight Loss? Rare genetic mutations have been described in medical literature in which the body is unable to produce lipoic acid synthase. Our team periodically reviews articles in order to ensure content quality. In addition, patients receiving this therapy did not experience any serious side effects. Can Alpha-Ketoglutaric Acid Boost Strength and Endurance? Guo Y, Jones D, Palmer JL, et al. Alpha-lipoic acid's ability to enhance calorie burning and promote weight loss has been exaggerated by many diet gurus and supplements manufacturers. Am J Med. To date, there have been no suggestions of a benefit, either in dealing with infectious causes of neuropathy or neuropathy induces by medications (such as chemotherapy). Cosmetics manufacturers often like to boast that their products benefit from the "anti-aging" properties of alpha-lipoic acid. A 2017 review of studies from the Yale University found that alpha-lipoic acid supplements, ranging in dose from 300 to 1,800 mg daily, helped prompt an average weight loss of 2.8 pounds compared to a placebo.. Synthesized in the human body, you can consume alpha-lipoic acid by eating meat and also some vegetables and fruits ().As a supplement it has shown great benefits when it comes to fighting against inflammation and oxidation. (More information) 3. Neuropathy is the medical term used to describe the pain, numbness, and abnormal sensations caused by nerve damage. 2011;19(8):1647-53. doi:10.1038/oby.2011.121, Mijnhout GS, Kollen BJ, Alkhalaf A, Kleefstra N, Bilo HJ. It is not a true vitamin because it can be synthesized in the body and is not necessary in the diet of animals. While considered safe, there are no guidelines directing the appropriate use of alpha-lipoic acid. Can N-Acetylcysteine Treat COPD, Diabetes, and Infertility? A review article notes that it is a powerful antioxidant and has been studied for its protective effects against radiation damage., Alpha-lipoic acid is generally considered safe when taken as an oral supplement or used as a topical ointment. Some scientists believe that oral supplements will not provide the therapeutic effect needed to prevent or treat diabetes and have begun investigating whether an intravenous (IV) infusion might help. Read our, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Lana Butner, ND, LAc, Medically reviewed by Richard N. Fogoros, MD. Alpha lipoic acid (ALA), also known as thioctic acid, is an eight-carbon organosulfur compound derived from caprylic acid (octenoic acid). 2017;18(5):594-601. doi:10.1111/obr.12528, Koh EH, Lee WJ, Lee SA, et al. It is sometimes referred to as a “universal antioxidant” because it is both water- and fat-soluble and can neutralize reactive oxygen species .It is marketed as a dietary supplement for this reason, and is also used as adjuvant therapy for neuropathy and to improve glycemic control. There was no association between the alpha-lipoic supplement dose and the amount of weight loss. If you eat a nutritious diet, your body will have all the raw materials it needs to make alpha-lipoic acid. 2 It also helps recycle other antioxidants like vitamin C and E as well glutathione. Metab Clin Exp. Understanding the Benefits of Cissus Quadrangularis. Alpha-lipoic acid is an organic molecule produced by the body, and it is soluble in both fat and water. Alpha-lipoic acid is an antioxidant that is made in the body which helps convert glucose into energy in addition to destroying free radicals Evidence also links alpha-lipoic acid to the regeneration of other antioxidants, like vitamin C, after they have attacked free radicals 1 3. DiPardo holds a Master of Science in organic chemistry from Yale University. … How do I know if I have an alpha-lipoic acid deficiency? Lipoic acid appears to have possible beneficial effects in the prevention of diabetes. Diabetol Metab Syndr. If I had diabetes, Alpha Lipoic Acid for neuropathy would be my first choice as a solution. It is scientifically proven to be highly effective at a way lower cost and WITHOUT any negative side effects. Alpha-lipoic acid is instead synthesized endogenously (in the body) through a series of biochemical processes involving fatty acids, proteins, and an enzyme known as lipoic acid synthase. In another third of cases, diabetes is the cause of the nerve damage, according to Din aceasta cauza, el patrunde cu usurinta prin membrana celulara si prin bariera hemato-encefalica, protejand toate celulele organismului, inclusiv neuronii, de actiunea radicalilor liberi. Doctors often refer to the condition as peripheral neuropathy, and symptoms may include numbness or a tingling or burning sensation in the hands and feet. Obesity (Silver Spring). Supplementation with lipoic acid transiently increases plasma and cellular concentratio… There is clear evidence that if you have yet to make ALA containing foods a staple of your diet, you should start now. By contrast, there is no evidence that the supplement can prevent or treat type 1 diabetes, the form of the disease typically associated with an immune system malfunction. In the November 2006 issue of "Diabetes Care," researchers describe a clinical trial of orally administered alpha-lipoic acid 3. Research suggests that there may some credence to these claims. In about a third of neuropathy cases, the damage arises from factors such as traumatic injury, alcoholism, tumors, genetic disorders or exposure to toxic substances or drugs like those used in cancer therapy. In the February 2004 issue of "Diabetic Medicine," researchers describe their meta-analysis of clinical data on the intravenous treatment of diabetic neuropathy with alpha-lipoic acid 3. Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney. There is growing evidence of at least some of these claims. Alpha-lipoic acid is an organic molecule produced by the body, and it is soluble in both fat and water. Cathy Wong is a nutritionist and wellness expert. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. The axon is a long projection from the cell body that carries nerve impulses away from the nerve cell and toward a receiving dendrite of a neighboring cell. At Healthfully, we strive to deliver objective content that is accurate and up-to-date. // Leaf Group Lifestyle. Lipoic acid is both water- and fat-soluble, and is thus widely distributed in both cellular membranes and the cytosol of eukaryotic and prokaryotic cells. (More information) 2. Much of the research involving alpha-lipoic acid has been centered on the prevention of diabetes and the management of diabetic nerve pain. Alpha lipoic acid (ALA) is a fat-soluble, sulfur-containing, vitamin-like antioxidant. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. As a dietary supplement, alpha-lipoic acid is not subject to strict regulation by the U.S. Food and Drug Administration (FDA). In addition to supplements, alpha-lipoic acid is synthesized in the body and found in many of the foods we eat, especially Brussels sprouts, spinach, broccoli, peas, brewer's yeast, potato, yams, carrots, rice bran, and organ meats. It is widely understood that alpha lipoic acid is manufactured endogenously within the human body and that its presence is essential for aerobic metabolism, or the means by which the body generates energy via breakdown of carbohydrates, amino … Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Eur J Endocrinol. These include Amanita mushroom poisoning, glaucoma , kidney disease , migraines , and peripheral arterial disease. Alpha-lipoic acid is sometimes taken as a supplement under the presumption it can improve certain metabolic functions, including fat burning, collagen production, and blood glucose control. In the November 2006 issue of "Diabetes Care," researchers describe a clinical trial of orally administered alpha-lipoic acid 3. Success & Drawbacks of Laser Therapy for Neuropathy & Surgery, "Diabetes Care"; Oral Treatment With Alpha-lipoic Acid Improves Symptomatic Diabetic Polyneuropathy: The SYDNEY 2 Trial; Rustem Samigullin, et al. Alpha-lipoic acid (ALA) is a mitochondrial compound involved in energy metabolism. So far, no cases of poisoning associated with taking too much of these supplements have occurre… In this video, you'll learn the nootropic benefits of Alpha-Lipoic Acid. Treatments for peripheral neuropathy include prescription medications, topical anesthetics, and alternative medicines such as Botulinum toxin, cannabinoids and alph-lipoic acid. Glaucoma and Alpha Lipoic Acid – Forty-five patients with stage I and II open-angle glaucoma (OAG) were administered either 75 mg of alpha-lipoic acid for 2 months or 150 mg for 1 month. Moreover, the duration of treatment appears to influence a person's body mass index (BMI), but not the person's actual weight. Alpha-lipoic acid is a compound found naturally inside every cell of the human body. That means that it can deliver energy immediately or warehouse it for future use. 15.8). It's most often used to help with diabetic neuropathy, which is a condition where you lose feeling in areas of your body as a complication of diabetes, like numbness, tingling, and burning pains in your legs and feet. Copyright © 2020 Leaf Group Ltd., all rights reserved. al. A control group of 31 patients with OAG were administered only local hypotensive therapy. 2) Diabetes. There have, in fact, been several reports of seizures and vomiting in children who have taken doses of 2,400 mg or greater.. Thank you, {{}}, for signing up. Support Care Cancer . ; November 2006, What Is Neuropathy? Effects of alpha-lipoic Acid on body weight in obese subjects. Acidul alfa lipoic, cunoscut si ca acid tioctic, este un antioxidant care poate fi solubil atat in apa, dar si in grasimi. Oftentimes, the damage is caused by the oxidative stress placed on the nerves by chronic diseases such as diabetes, Lyme disease, shingles, thyroid disease, kidney failure, and HIV. After five weeks of once-a-day treatment, it was clear that the 600 mg dose alleviated neuropathy symptoms and kept side effects of nausea, vomiting and vertigo at acceptable levels. Alpha-lipoic acid is one of the fatty acids from the mitochondrial family of fatty acids that fights against inflammation and oxidation. Their analysis indicates that a treatment regimen consisting of an intravenous dose of 600 mg of alpha-lipoic acid per day for three weeks significantly alleviates the symptoms of diabetic neuropathy 3. Alpha-lipoic acid is an organic compound that acts as a powerful antioxidant in your body. As such, alpha-lipoic acid is not considered an essential nutrient because you don't need it to obtain it from food. It occurs in all cells, and plays a role in the metabolism of glucose. 2012;2012:456279. doi:10.1155/2012/456279, Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. 3 Levels of glutathione especially tend to decline with age and alpha lipoic acid may actually offer a way to counter this. Alpha-lipoic acid, an antioxidant produced by the body, is one possible treatment for peripheral neuropathy. Its primary role is to convert blood sugar (glucose) into energy using oxygen, a process referred to as aerobic metabolism. By doing so, you can be better assured that the supplements contain the listed ingredients and are manufactured to the highest quality standards. Can Stinging Nettle Treat Arthritis, Allergies, and Enlarged Prostate? Patients should consult their doctor before taking any dietary supplement. Overview Information Alpha-lipoic acid is a vitamin-like chemical called an antioxidant. Also, in some cases, alpha lipoic acid can have positive showings against thyroid conditions that harm the human body. Alpha-lipoic acid also serves as an antioxidant that can work to neutralize harmful free radicals throughout the body, according to the University of Maryland Medical Center 2. A nerve cell consists of the cell body, the dendrites and a single axon. Animal studies strongly suggest that alpha lipoic acid can alter thyroid hormone levels. As such, people taking thyroid medications such as levothyroxine should be monitored by their doctor if alpha lipoic acid is being used. It is commonly taken with L-Carnitine supplements, as they are related in mechanisms. Do Agaricus Mushrooms Have Health Benefits? Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, herbalist, and integrative medicine doctor practicing in Santa Monica, California. 2015;19(6):730-2. doi:10.1016/j.ejpn.2015.07.002, Bao Y, Gao C, Hao W, et al. doi:10.1016/j.amjmed.2010.08.005, Pagano C, Calarco P, et. Its antioxidant activity may be responsible for its ability to alleviate the tingling, burning and numbness in people who have experienced the nerve damage associated with peripheral neuropathy. Alpha-lipoic acid has long been believed to influence weight and health by altering the lipid (fat) composition in the blood. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. The only exceptions are organ meats and certain leafy and root vegetables. Because of this, the terms can be used interchangeably. There are two forms of lipoic acid; α-lipoic acid (1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid or thioctic acid) and the reduced form dihydrolipoic acid (6,8-dimercaptoocatanoic acid or 6,8-thioctic acid) (Fig. Please check with the appropriate physician regarding health questions and concerns. Development and characterization of new topical hydrogels based on alpha lipoic acid—hydrotalcite hybrids. Recent research suggests this may not be so. With that being said, everything from body weight and age to liver function and kidney function can impact what is safe for you as an individual. Alpha-lipoic acid has also been researched as a treatment for many other conditions. Alpha-lipoic acid is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names. Alpha lipoic acid plays a role in physiological functions as well as energy production in the body. An alpha-lipoic acid deficiency is practically unheard of. Patients with neuropathy incur damage to the axon of peripheral nerve cells. A 2012 review of studies from the Netherlands concluded that a daily 600-mg intravenous dose of alpha-lipoic acid given over three weeks provided "significant and clinically relevant reduction in neuropathic pain.". Eur J Paediatr Neurol. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. A nerve cell consists of the cell body, the dendrites and a single axon. Alpha Lipoic Acid (ALA) is a potent antioxidant, sometimes used in the treatment of diabetes mellitus; diabetic neuropathy; cognitive diseases or conditions (dementia, Alzheimer's), vision problems (glaucoma, retina damage, macular degeneration, Wilson's disease), HIV/AIDS, amanita mushroom poisoning, and alcoholic liver disease. This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage. Cosmetics 2019;6(2), doi:10.3390/cosmetics6020035, Tolunay O, Çelik T, Kömür M, Gezgin AE, Kaya MS, Çelik Ü. It is believed by some that alpha-lipoic acid, given in large enough doses, can counter this stress by exerting potent antioxidant activity. Studies have shown that ALA creams are effective in the treatment of photodamaged skin. The aim of the study was to test three antioxidants — alpha lipoic acid, metformin, and glimepiride. It is estimated that fewer than one of every 1,000,000 people are affected. Alpha-lipoic acid is also considered an antioxidant, meaning that it can neutralize harmful compounds called free radicals that damage cells at the genetic level..