Arch Intern Med. [Medline]. Ultsch B, Köster I, Reinhold T, Siedler A, Krause G, Icks A, et al. 2000 Jun. 2017 Jul 11. A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster. 335(1):32-42. Herpes zoster and postherpetic neuralgia: prevention and management. [Medline]. [Full Text]. [Medline]. Bert RJ, Samawareerwa R, Melhem ER. [Medline]. [Medline]. [Medline]. A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. Available at Chronister CL. 2018 Feb 06; Accessed: February 6, 2018. 77(3):245. 2005 Aug. 20(8):748-53. Strangfeld A, Listing J, Herzer P, Liebhaber A, Rockwitz K, Richter C, et al. 2005 Jun 2. [Medline]. Forbes HJ, Bhaskaran K, Thomas SL, Smeeth L, Clayton T, Langan SM. [Medline]. [Medline]. 62(2):81-97. 2012 Nov 15. PeerJ. Bone Marrow Transplant. 85(2A):84-9. 2007 May. Civen R, Chaves SS, Jumaan A, Wu H, Mascola L, Gargiullo P, et al. Analgesic effect of lidocaine patch 5% in the treatment of acute herpes zoster: a double-blind and vehicle-controlled study. 60 (44):1528. 2009 Feb 25. Available at 2017 Jun. Shingles, or herpes zoster, occurs when the dormant chickenpox virus is reactivated in nerve tissues. Kurokawa I, Kumano K, Murakawa K. Clinical correlates of prolonged pain in Japanese patients with acute herpes zoster. 1998 Mar. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. Circulation. 2009 Mar-Apr. 1997 Jun. Brain Nerve. 1998 Feb. 74(868):101-3. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. 63 (6):959-65. 1995 Jul. A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. Review of external ocular disease associated with aids and HIV infection. 2003. Pediatr Infect Dis J. Post-mortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR. 123(2):89-96. [Guideline] Centers for Disease Control and Prevention (CDC). Gerodontology. [Medline]. Acta Anaesthesiol Scand. [Medline]. If the shingles rash is in or on your ear, you could develop hearing or balance problems, and in rare instances, the virus might attack your brain or spinal cord. Rauck RL, Irving GA, Wallace MS, Vanhove GF, Sweeney M. Once-Daily Gastroretentive Gabapentin for Postherpetic Neuralgia: Integrated Efficacy, Time to Onset of Pain Relief and Safety Analyses of Data From Two Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies. Clin Infect Dis. 27(2):159-76. Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy. Acta Dermatovenerol Alp Panonica Adriat. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Indian J Dermatol Venereol Leprol. 2000 Nov 23. The incidence of recurrent herpes simplex and herpes zoster infection during treatment with arsenic trioxide. Anesth Analg. Ono N, Sakabe A, Nakajima M. [Herpes zoster oticus-associated jugular foramen syndrome]. Progressive outer retinal necrosis caused by varicella-zoster virus in children with acquired immunodeficiency syndrome. 2017 Feb. 20 (2):E209-E220. Diseases & Conditions, 2002 27(5):310-6. [Medline]. Gelb LD. Patient consented to picture distribution for educational use; written permission on file. [Medline]. Gastrointestinal complications of dermatomal herpes zoster successfully treated with famciclovir and lactulose. [Medline]. Joseph S Eastern, MD Clinical Assistant Professor, Department of Internal Medicine, Section of Dermatology, University of Medicine and Dentistry of New Jersey; Clinical Assistant Professor, Seton Hall University School of Graduate Medical Education [Full Text]. J Eur Acad Dermatol Venereol. [Medline]. Dirk M Elston, MD is a member of the following medical societies: American Academy of DermatologyDisclosure: Nothing to disclose. Typically, it is clinically indistinguishable from varicella (chickenpox). J Pain Symptom Manage. 1995. Photos of People with Shingles. 43 (2):168-172. Ned Tijdschr Geneeskd. Note unilateral distribution of rash and how V1 distribution may extend to tip of nose. Peck R, Gimple SK, Gregory DW, Youree B. 1-29. 2019 Jan 9. BMC Fam Pract. [Medline]. Ophthalmic Res. [Medline]. 2001 Sep. 132(3):421-3. 2008 Feb. 115(2 Suppl):S13-20. 23(12):1317-20. Paquin R, Susin LF, Welch G, Barnes JB, Stevens MR, Tay FR. [Medline]. WARNING: Some of these photos might be unsuitable for children. J Endod. Caple J. Varicella-zoster virus vaccine: a review of its use in the prevention of herpes zoster in older adults. 2008 Feb. 115(2 Suppl):S35-8. Huang J, Huang J, Xiang Y, Gao L, Pan Y, Lu J. [Medline]. Comparison of the Tzanck test and polymerase chain reaction in the diagnosis of cutaneous herpes simplex and varicella zoster virus infections. 2001 May. 18(1):28-30. Curran D, Patterson BJ, Van-Oorschot D, Buck PO, Carrico J, Hicks KA, et al. Schmader K, George LK, Burchett BM, Pieper CF. Clin Infect Dis. Child with shingles who had a history of leukemia. Prevention of post-herpetic neuralgia: acyclovir and prednisolone versus epidural local anesthetic and methylprednisolone. Dahlmann A. 2010 Mar. 1997 Sep. 36(9):667-72. Your doctor can usually diagnose your shingles … [Medline]. [Guideline] Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. If you have a shingles rash that is on your eye, eyelid or forehead (such as in the shingles pictures below), you should go see a doctor as soon as possible. 70 (2):295-296. Switch Between JAK and TNF Inhibitors Safe, Effective for Rheumatoid Arthritis, 14 Rashes You Need to Know: Common Dermatologic Diagnoses, Rinse and Repeat? Pain. [Medline]. [Medline]. Cornea. September 13, 2017; Accessed: September 20, 2017. N Engl J Med. Collaborative Famciclovir Herpes Zoster Study Group. 1994 Jun. 1999 Dec. 73(12):10514-8. Neonatal herpes simplex virus is addressed separately. BMJ. 56:1-40. Herpes zoster ophthalmicus following bone marrow transplantation in children. 157(11):1209-13. [Medline]. [Full Text]. [Medline]. [Medline]. [Medline]. Eur J Neurol. Br J Ophthalmol. 2014. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Shingles on face. Reg Anesth Pain Med. 301(7):737-44. encoded search term (What is disseminated herpes zoster (shingles)?) Kim MC, Yun SC, Lee HB, Lee PH, Lee SW, Choi SH, et al. Ophthalmology. 125(3):285-91. Child with shingles who had a history of leukemia. Source: CDC . According to Infectious Disease Physicians, 2001 Cresswell F, Eadie J, Longley N, Macallan D. Severe Guillain-Barré syndrome following primary infection with varicella zoster virus in an adult. 42(2):51-63. Khaliq W, Alam S, Puri N. Topical lidocaine for the treatment of postherpetic neuralgia. Pediatr Int. 1983 Jun 16. Fernandes NF, Malliah R, Stitik TP, Rozdeba P, Lambert WC, Schwartz RA. [Medline]. Karlin JD. Factors influencing pain outcome in herpes zoster: an observational study with valaciclovir. 1997 Jun 9. Marin M, Güris D, Chaves SS, Schmid S, Seward JF.